MRSA persists in the kidney's hyperosmotic inner medulla by exploiting tissue polyamines and evading immune detection, with the process influenced by osmolality and pH.
Science Translational Medicine
American Association for the Advancement of Science · General Science & Medicine · ISSN 1946-6234
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A single 4-hour topical therapy eradicates all mites and eggs in a human-relevant porcine model of severe scabies, outperforming standard oral ivermectin.
Wrist-worn accelerometer-based DAPS accurately measures upper-limb motor recovery after stroke, reducing clinical trial sample sizes by over 60%.
Prime editing achieves up to 70% correction of GATA2 deficiency in human hematopoietic stem cells, enhancing engraftment and safety profiles.
Combining FAK inhibitor and RAF/MEK clamp avutometinib with KRAS G12C inhibitor enhances tumor suppression in NSCLC models, overcoming resistance mechanisms.
Cranial bone marrow-derived monocytes drive neuroinflammation in chronic traumatic brain injury, with 40% reduction in neurofilament light chain levels after fenofibrate treatment.
Orally administered danegaptide significantly improves retinal vascular barrier function in NPDR, showing safety and early efficacy in a phase 1b trial with 24 patients.
SCRMP-mediated SUMOylation of CSNK2B enhances DNA repair, driving cisplatin resistance in small cell lung cancer with a 128-amino acid protein involved.
Drug repurposing uncovers 10 uterus-selective drugs, including fosaprepitant and ciclesonide, that inhibit preterm labor contractions with high therapeutic indices.
UVB exposure triggers distinct epidermal dysregulation and monocyte-derived dendritic cell recruitment in SLE skin, with 24-hour single-cell insights revealing key inflammatory pathways.
CXCL1-CXCR2 signaling drives leptomeningeal metastasis growth and predicts poor response to radiation therapy, with higher levels linked to worse outcomes.
Kamuvudine-9, an NRTI derivative, prevents neurological deficits and reverses paralysis in a mouse model of multiple sclerosis, showing neuroprotective effects.
RINL acts as a repressor of renal uric acid excretion, with mutations increasing serum uric acid levels in humans and mice, highlighting its role in hyperuricemia.
A CRISPR-based nanodroplet assay accurately identifies 15 mycobacterial species within 3.5 hours, surpassing traditional culture methods in speed and precision.
Engineered Escherichia coli Nissle 1917 delivers tumor-specific chemoimmunotherapy, achieving potent antitumor effects and systemic immune memory in mouse models.
Single-nucleus RNA sequencing reveals genotype-specific cellular remodeling in hypertrophic cardiomyopathy across disease stages, with a 20-fold increase in proarrhythmogenic cardiomyocyte states.
Antibodies against HLA-E-VL9 boost NK and CD8+ T cell killing of tumor and HIV-infected cells, showing potential for immunotherapy.
Six novel mutations in Pneumocystis jirovecii's IMPDH enzyme confer resistance to mycophenolic acid, emerging globally between 2005 and 2019 under human drug pressure.
A reversible lab-on-a-contact lens detects tear serotonin with a 72 picomolar sensitivity, enabling real-time monitoring of stress biomarkers in tears.
Monoclonal antibodies targeting MMP-9 reduce neuropathic pain and improve nerve healing in diabetic mice, showing promise for treating diabetic peripheral neuropathy.
Intravenous gene therapy extends lifespan up to nearly three times in a feline model of Sandhoff disease, with dose-dependent improvements in clinical and biochemical outcomes.
Deep learning analysis of spleen MRI features reveals 10 associations with coronary artery disease in over 44,000 participants.
Engineered TCR T cells targeting MCPyV oncoprotein achieved tumor regression in MCC but faced immune escape due to HLA class I silencing.
Closed-loop auditory stimulation during sleep increases cerebrospinal fluid flow waves by aligning with neural slow-wave peaks in humans.
A five-nanobody recombinant antivenom effectively neutralizes venom from multiple Indian cobra and king cobra species, preventing death in mice models.
Proteomics identified disease-associated variants in 64% of undiagnosed rare disease patients after genome sequencing, enhancing diagnostic success.
Viral rebound in SIV-infected rhesus macaques after ART discontinuation originates from limited tissue sites, primarily the gastrointestinal tract, involving 1 to 38 lineages per animal.
Elevated translocator protein levels in skull bone marrow are linked to chronic pain, with increases observed in 250 individuals across different conditions.
MicroRNA-224-5p promotes pulmonary vascular remodeling and worsens PAH, with inhibition reducing disease severity in preclinical models.
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