Distinct tau PET dynamics in early versus late age-of-onset Alzheimer's disease.

In amyloid PET-positive, cognitively impaired participants, early-onset Alzheimer’s disease shows higher baseline 18 F-flortaucipir tau PET burden and faster longitudinal tau PET increase than late-onset disease.

• Why it matters: EOAD and LOAD progress differently, but it is unclear whether tau PET burden and its clinical links differ by age of onset.
• What they did: The study compared baseline and longitudinal tau PET dynamics with 18 F-flortaucipir in EOAD (n = 390) versus LOAD (n = 211) from EOAD and ADNI cohorts, relating tau PET to amyloid PET and global cognition.
• The result: EOAD had broader neuroanatomical involvement and stronger tau PET associations with amyloid PET and global cognition, and tau PET rose more rapidly in EOAD independent of amyloid PET and clinical stage, validated in an additional EOAD ADNI sample.

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