Sleep-like slow waves during wakefulness are associated with hallucinations and poorer cognition in Parkinson's disease.

Sleep-like slow waves during wakefulness occur more frequently in a cohort of 84 nondemented Parkinson’s disease patients than in 30 healthy older adults.

• Why it matters: It is unclear whether wakeful slow-wave activity is altered in Parkinson’s disease and whether it relates to hallucinations or cognitive decline.
• What they did: The study compared sleep-like slow-wave occurrence and features between 84 nondemented patients with PD and 30 healthy older adults, then tested links to hallucinatory traits and cognitive performance.
• The result: In patients with PD, hallucinatory traits were associated with higher SLSW amplitude, especially over frontocentral regions, and more prominent SLSWs were linked to poorer cognitive functions.

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