Research area · week to 3 Oct 2026

Multiple Sclerosis Research Studies

Moving in bioRxiv, medRxiv, Gastroenterology, mSystems, Nature Genetics, Nature Medicine, Environmental research, Nature.

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Gastroenterology · 1 Oct 2026 · Letter
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Generalizability of the MetALD-ALD Prediction Index in Asian Populations.
Gastroenterology · 1 Oct 2026 · Letter
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Chronic lesion expansion persists in secondary progressive multiple sclerosis and is associated with neurodegeneration
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363839
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Axonal entry and retrograde transport define HSV-1 latency establishment and reactivation potential in neurons
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754144
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CNM-Au8 Treatment Is Associated With Reduced Chronic Lesion Tissue Expansion in Relapsing-Remitting Multiple Sclerosis
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363841
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Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain
bioRxiv · 25 Sept 2026 · Preprint
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Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity.
mSystems · 22 Sept 2026 · Journal Article
Microbial and metabolic signatures, especially microbial metabolites like p-cresols and indoles, drive CNS autoimmunity severity in a mouse model of MS, with diet-microbiome interactions shaping disease outcomes.
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Age-associated Autoimmunity Driven by T cell Immunosenescence
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.07.698250
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State-Dependent 3D Enhancer Architecture Resolves a Shared Schizophrenia and Multiple Sclerosis Ketone and Lactate Sensing Logic Gate
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.30.735650
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EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.
Nature Medicine · 16 Sept 2026 · Journal Article
EBV reactivation in peripheral immune cells up to three months before MS relapse predicts disease exacerbation, with elevated viral transcripts and atypical B cell expansion.
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Albumin-fused interleukin-10 prevents experimental autoimmune encephalomyelitis by promoting immunoregulation in the secondary lymphoid organs
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.10.717764
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Aflatoxin exposure and cognitive performance in Mexican adolescents.
Environmental research · 11 Sept 2026 · Journal Article
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https://jclub.com.au/a/42727913
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Multiscale Modelling of Multiple Sclerosis Initiation and Progression
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.04.697229
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Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.
Nature Genetics · 1 Sept 2026 · Journal Article
Inhibitory neurons are a key target in MS susceptibility, with seven loci, including STAT3, showing altered expression exclusively in these cells.
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https://jclub.com.au/a/42706309
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Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics.
Nature Genetics · 1 Sept 2026 · Journal Article
Multiancestry GWAS and multiomics analyses reveal 22 novel susceptibility loci and spatiocellular features of multiple sclerosis genetics across diverse populations.
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Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.
Nature Medicine · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42426222
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Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.25.747169
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Regulation-Driven Variation in Utilization and Cost of B-Cell Depleting Therapies for Multiple Sclerosis: A Cross-National Study
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.19.26360842
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Integrative multicohort analysis reveals consistent sex differences in gut microbiota of multiple sclerosis patients.
mSystems · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42484622
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Misfolded proteolipid protein and amyloid deposition in the multiple sclerosis brain
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.09.743756
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Re-examining the lower speed boundary of preferred coordination ratio constancy: estimator dependence and competing breakpoint regions
bioRxiv · 16 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.26.720900
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Multiplexed temporal SWCNT biosensor combined with convolutional autoencoding identifies ALS-specific serum protein corona signatures
medRxiv · 10 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.08.26354966
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Antigen presentation by CD40(+)MHC-II(+) astrocytes promotes CNS autoimmunity.
Nature · 5 Aug 2026 · Journal Article
CD40(+)MHC-II(+) astrocytes actively promote CNS autoimmunity by enhancing pathogenic T helper 17 responses, with 40% of astrocytes displaying this phenotype in disease models.
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