The abstract is read at the publisher; the summary is JClub's.
Platelet-to-lymphocyte ratio is modestly higher in Neuromyelitis Optica Spectrum Disorders patients than in healthy subjects (pooled MD 23.99 [6.03; 41.96]).
- Why it matters: It is unclear whether simple inflammatory ratios like MLR and PLR reliably distinguish NMOSD patients from healthy controls, given inconsistent findings across studies.
- What they did: A systematic review and meta-analysis pooled mean differences in PLR and MLR from studies comparing NMOSD patients with healthy controls, using MD with 95% confidence intervals.
- The result: MLR was not higher in the main analysis (pooled MD 0.125 [-0.114; 0.363]), though age- and sex-matched subgroup analysis and leave-one-out excluding an outlier suggested a significant increase; PLR showed a modest overall increase but was non-significant in age- and sex-matched subgroup analysis.
The findingWhy it mattersWhat they didThe result
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