Meta-analysis of melanoma miRNome reveals 24 diagnostic and 23 prognostic miRNA signatures that regulate metabolic plasticity and stress resistance in melanoma progression.
- Open access
- 2 cites
MicroRNA in disease regulation
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MATR3 is crucial for oocyte growth and maturation, with its absence causing growth restriction and infertility in mice, highlighting its essential dual role.
- Open access
Modified hm5C self-amplifying RNA enables over five weeks of sustained gene expression in mouse brain cells and more than 76 days in human brain slices.
- Open access
- 1 cites
A cBSA-mediated miRNA delivery system was developed in Camellia sinensis, enabling efficient in vivo functional validation of miRNA-target modules, exemplified by a 72% gene silencing.
- Open access
The miRNA-ROS interactome is a conserved, multi-layered regulatory network crucial for plant stress resilience, coordinating ROS homeostasis across cellular compartments.
- Open access
CIRI3 detects and quantifies circRNAs in terabyte-scale RNA-seq datasets with ten times greater speed and higher accuracy than existing tools.
- Open access
- 8 cites
PCBP2 enhances miR-93-5p-mediated repression of GDF11, a tumor suppressor, promoting proliferation and invasion in hepatocellular carcinoma cells.
- Open access
miR-34a-5p acts as a radiosensitizer and biomarker, with reduced expression linked to poor treatment response and survival in esophageal adenocarcinoma.
- Open access
A three-miRNA panel (hsa-miR-29b-3p, hsa-miR-19b-3p, hsa-miR-30e-5p) achieves 91.67% accuracy in early-stage ovarian cancer detection using machine learning.
- Open access
Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37, promoting tumor progression by impairing immune defenses and enhancing invasion.
- Open access
miR-142 and miR-124 isoforms significantly improve dendritic cell reprogramming efficiency and fidelity, with miR-142 enhancing anti-tumor immunity in vivo.
- Open access
Epigenetic and chromatin remodeling mechanisms critically influence mesenchymal stem/stromal cell function in osteoarthritis, with chromatin regulation affecting key cellular responses.
- Open access
The miR-15b/16-2 cluster acts as a tumor suppressor in T-cell acute lymphoblastic leukemia, impairing leukemic growth and progression by downregulating key oncogenes.
- Open access
Pyruvate carboxylase (PC) acts as a novel RNA sensor, mediating over 100-fold interferon induction via miRTC14 in antiviral immunity.
- Open access
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