Longitudinal miRNA-mRNA Profiling Reveals Network Reorganization in Preeclampsia

Preeclampsia shows marked temporal reorganization of maternal whole-blood miRNA–mRNA regulatory networks, with strongly opposing temporal effect sizes (Spearman ρ = -0.82, P …).

• Why it matters: The timing of molecular dysregulation across pregnancy in preeclampsia is not well defined, limiting understanding of when regulatory networks shift.
• What they did: Maternal whole-blood RNA sequencing was performed longitudinally in early (10–18 weeks) and late pregnancy (32–38 weeks) from 43 PE cases and 106 normotensive controls, including 109 paired samples; differential expression, temporal classification, pathway enrichment, and miRNA–mRNA network integration were used, with key interactions validated in HTR-8/SVneo trophoblast cells.
• The result: The opposing temporal miRNA–mRNA effects imply that regulatory relationships reorganize across gestation in PE, enabling mechanistic prioritization of network interactions for follow-up.

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