Identification of T-Cell specific signature miRNAs and target pathways in Psoriasis

Fourteen miRNAs are dysregulated in psoriatic T cells, mapping to 256 downstream targets across 15 T cell–associated signaling pathways.

• Why it matters: Psoriasis involves T cells in lesional and systemic inflammation, but the molecular basis of T cell–linked miRNA changes remains limited.
• What they did: The study compiled literature and datasets to identify altered miRNAs in psoriatic T cells, then predicted targets and enriched 15 signaling pathways tied to T cell functions.
• The result: Five of 14 miRNAs showed a significant expression increase in enriched CD3+ T cells from blood of psoriatic patients versus healthy subjects, supporting candidate miRNA-target components for diagnostics and therapy.

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