Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis severity by enhancing ECM remodeling and protecting enteric neurons, with a 50% decrease in inflammation.
Cancer-related gene regulation
Moving in bioRxiv, eLife, Nature Communications, Blood, Cancer Discovery, Cellular & molecular immunology, Circulation, Frontiers in Genetics.
- Moved this week
- 0
Rebuilt
Moved this week
Nothing in this area has moved yet this week.
Latest in Cancer-related gene regulation
Newest first · last 60 days
PRMT1-SFPQ pathway controls intron retention to regulate matrix gene expression during craniofacial development, impacting tissue-specific splicing in CNCCs.
- Open access
Set1 interacts with over 100 proteins, expanding its known roles to include chromatin regulation, RNA processing, and nuclear-cytoplasmic transport in Saccharomyces cerevisiae.
- Open access
Altered m(6)A methylation patterns in mRNAs and lncRNAs are significantly associated with major depressive disorder, affecting over 600 RNAs in patient blood samples.
- Open access
Biallelic epigenetic inactivation of ZFHX3 occurs at a recurrence rate comparable to TP53 in prostate cancer, promoting oncogene upregulation and metastasis.
- Open access
Human FTO acts as an m6A demethylase in tomato, accelerating flowering by up to 50% under low-temperature stress conditions.
- Open access
TNG961 is a potent, selective oral degrader of HBS1L that effectively treats FOCAD-deleted cancers, including PRMT5 inhibitor-refractory models.
- Open access
Loss of tRNA methyltransferase Trmt61a reduces m1A modification, impairing Tfrc translation and causing iron deficiency that damages fetal liver HSPCs.
- Open access
- 1 cites
Dendritic spine nanostructure analysis reveals that increased Ecrg4 expression links to schizophrenia-related spine abnormalities in mouse models.
- Open access
Polyamines act as endogenous buffers of redox-active iron, with depletion increasing labile iron and promoting ferroptosis in mammalian cells.
- Open access
- 4 cites
Methylation-sensitive SMiLE-seq reveals 11 human transcription factors that prefer methylated DNA and 13 that avoid it, expanding understanding of DNA modification effects.
- Open access
- 5 cites
Follow this area in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1746
- Environ Res485
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ205
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- Curr Biol116
- J Exp Bot115
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4