Programmable bioengineering and scalable bioprocessing enable fivefold increases in tailored rhamnolipid production from safe, non-pathogenic cell factories.
Microbial metabolism and enzyme function
Moving in Biotechnology advances, Applied and environmental microbiology, bioRxiv, Nature Chemical Biology, eLife, Environmental research, Journal of bacteriology, Journal of Experimental Botany.
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Latest in Microbial metabolism and enzyme function
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Enzymatic CO2 fixation pathways can be optimized to convert CO2 into valuable products, with potential for scalable, sustainable biocatalytic applications.
Microorganisms efficiently metabolize liquid n-alkanes, enabling complete mineralization and biocatalytic conversion for environmental and industrial applications.
Cryo-EM structures reveal a bifunctional TDM enzyme with a novel channeling pathway that guides formaldehyde to a remote tetrahydrofolate site, enhancing metabolic efficiency.
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Engineered Escherichia coli with an orthogonal energy system enables growth and chemical production from CO₂ and methanol, doubling growth rate and high biomass yield.
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A novel Rieske oxygenase system in Pseudomonas putida NCIMB 9866 enables successive oxidation of 2,4-xylenol’s ortho-methyl group into a valuable pharmaceutical precursor.
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A conserved RH/QxxR motif enables widespread use of noncanonical redox cofactors in natural enzymes, with Bos taurus ALDH3a1 achieving unprecedented turnover with NMN+.
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Balanced intracellular formate levels are essential for maintaining pH(i), CO2 homeostasis, and energy metabolism during mixed-acid fermentation in Escherichia coli, with disruptions causing growth defects.
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