Machine-learning-designed minimal ligand-binding domains enable efficient allosteric switches without global conformational change, facilitating diverse biosensors and synthetic systems.
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Metalloenzymes and iron-sulfur proteins
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YdzF, a non-canonical regulator, controls bacterial nanotube formation in Gram-positive bacteria through YmdB-dependent flagellar gene regulation.
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Low-sulfur conditions induce a conserved set of genes in rice roots, with SULTR1;1 promoting root growth under sulfur limitation in both upland and lowland varieties.
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Reciprocal regulatory networks coordinate sulfur with phosphorus, nitrogen, and iron in plants, with key transcription factors controlling nutrient homeostasis in Arabidopsis thaliana.
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Glutaredoxins in plants have diversified into over 30 isoforms across four classes, with key roles in metabolism driven by structural and functional evolution.
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Microbial communities influence plant iron-sulfur metabolism by reprogramming plant networks and enhancing nutrient use efficiency, with potential to improve crop resilience.
The human Mic60-Mic19 subcomplex forms a dynamic tetrameric structure that acts as a diffusion barrier at mitochondrial crista junctions, with a key role in mitochondrial regulation.
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Engineered Escherichia coli with an orthogonal energy system enables growth and chemical production from CO₂ and methanol, doubling growth rate and high biomass yield.
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Coenzyme A activates TLR4 and boosts IL-4-driven macrophage activation via MyD88, revealing a new metabolic pathway influencing immune responses.
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Decreasing cathodic potential from -0.90 to -1.05 V in microbial electrolysis cells enhances methane production from CO by over tenfold, reaching 1.410 mmol.
Metal atom catalysts enable atomic-level control of nitrate-to-ammonia conversion, with recent systems achieving breakthroughs in activity and selectivity.
Gut-derived pantothenic acid from Bacteroides fragilis improves metabolic syndrome by restoring gut barrier function and reducing inflammation.
Elm1 and Gin4 kinases are essential for septin stability and actomyosin ring organization during cytokinesis in Saccharomyces cerevisiae, with Gin4 directly interacting with Hof1.
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AvaS enzyme catalyzes pyridoxal-phosphate-dependent biosynthesis of ava 2 C-modified tRNA in Pseudomonas aeruginosa, impacting AUA decoding efficiency.
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Hyperthermophilic archaeal nitrogenase from Methanocaldococcus infernus exhibits the highest known activity and thermostability, with a melting temperature near water's boiling point.
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The GmMYB093-GmCYP90A1-BR module enhances soybean adaptation to iron deficiency by regulating key physiological and molecular responses.
Overexpression of frataxin in Arabidopsis thaliana enhances growth and modulates iron metabolism under both iron deficiency and excess, with a 30% increase in rosette size.
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Dietary interventions cause tissue-specific changes in cytosolic and mitochondrial tRNA abundance and modification patterns in mice, with notable effects on decoding efficiency.
Pyridoxal 5'-phosphate (PLP) acts as a photoenzymatic cofactor enabling asymmetric radical-radical cross-couplings, expanding enzymatic bond formation capabilities.
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