Plant-microbiome interactions provide novel insights into the regulation of iron-sulfur metabolism in plants.

Microbial communities influence plant iron-sulfur metabolism by reprogramming plant networks and enhancing nutrient use efficiency, with potential to improve crop resilience.

• Why it matters: Understanding how plant-microbiome interactions regulate Fe-S metabolism is crucial for developing sustainable agricultural strategies, especially under nutrient limitations and environmental stress.
• What they did: Researchers examined the role of root-associated microbes and synthetic microbial communities (SynComs) in modulating Fe and S homeostasis through metabolite exchange, hormonal pathways, and redox signalling, using multi-omics and experimental approaches.
• The result: Findings reveal microbial strategies like siderophore-mediated Fe mobilization and S metabolite release that optimize nutrient use, paving the way for AI-driven design of microbial consortia to enhance crop productivity in challenging environments.