The transactivation domain (TAD) is essential for nuclear import of phosphorylated STAT5, with two key residues D754 and D758 critical for this process.
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Cytokine Signaling Pathways and Interactions
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Selective targeting of IL-6 trans-signalling pathway offers potential for safer, more precise therapies, as it accounts for distinct roles in disease and homeostasis.
Strong, sustained type I IFN signaling intrinsically impairs IFNγ responses in macrophages, increasing susceptibility to tuberculosis in Mycobacterium tuberculosis infection.
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Pyruvate carboxylase (PC) acts as a novel RNA sensor, mediating over 100-fold interferon induction via miRTC14 in antiviral immunity.
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