Venetoclax-controlled DROP-CAR T cells effectively regulate tumor targeting and reduce off-tumor toxicity through dose-dependent cell-cell interaction modulation.
- Open access
- 2 cites
Monoclonal and Polyclonal Antibodies Research
Moving in bioRxiv, Nature, Biotechnology advances, Cancer Discovery, Cell Reports, Cellular & molecular immunology, eLife, Molecular Cell.
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Latest in Monoclonal and Polyclonal Antibodies Research
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Metastasis promotes tumor immunogenicity by producing migrasomes that deliver antigens and activate immune responses, reducing metastatic growth.
- Open access
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and degradation, limiting inflammatory responses and disease severity.
CAR T cells targeting surface U5 snRNP200, an RNA-binding protein absent from normal hematopoietic precursors, effectively treat AML and B-cell ALL with improved safety.
- Open access
Re-examining the temperate phage life cycle reveals complex interactions beyond traditional models, emphasizing the integration of properties previously considered separate.
CAR-T cell therapies and cancer nanovaccines show promise but face distinct translational challenges, with recent advances highlighting their potential to reshape cancer treatment.
- Open access
AlphaFold2-based PAbFold pipeline accurately predicts linear antibody epitopes from sequence data, successfully identifying epitopes for known and novel antibodies.
- Open access
Tumor-associated macrophages (TAMs) are the main nonmalignant cells accumulating albumin in tumors, with FcRn-mediated uptake crucial for their maturation and immunotherapy response.
- Open access
Combinatorial deep mutational scanning reveals epistatic superbinders that bind 3- to 5-fold tighter than existing PIN1 WW-domain binders.
- Open access
Proximity-guided graph learning identifies 248 tumour-associated proximity antigens, revealing spatial relationships that enhance targeted cancer therapy.
- Open access
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