Co-exposure to environmental lead and hypertension significantly worsens anxiety and depression in mice, with a 2.5-fold increase in behavioral deficits compared to single exposures.
Trace Elements in Health
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Prenatal arsenic exposure from metal mixtures significantly increases offspring blood pressure, with a 4.41 mm Hg rise in systolic BP linked to maternal levels.
Serum lithium, nickel, cobalt, and manganese are linked to a 56.3% greater risk of chronic kidney disease in Chinese older adults, with lithium contributing most strongly.
Intracellular zinc directly inhibits the sperm-specific Slo3 potassium channel by up to micromolar concentrations, with slow dissociation dynamics, affecting sperm capacitation.
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Yersinopine is a primary zinc acquisition system in Yersinia pseudotuberculosis, essential for growth under zinc-limited conditions, unlike in Yersinia pestis where it is inactive.
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Copper ion-induced MYH9 polymerization triggers cuproptosis, with 50% of drug-resistant tumor cells showing elevated copper levels facilitating this process.
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A leucine-rich repeat receptor kinase called CERI is essential for systemic nitrogen-demand signalling in plants, with CERI loss impairing this process in Arabidopsis.
Zn-Se co-application in wheat reduces grain Se levels by 50% but still meets human nutritional requirements, revealing complex multi-scale antagonism mechanisms.
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Manganese uptake via Sit and MntH is essential for UPEC CFT073 to resist oxidative stress and establish infection during urinary tract infections.
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Inhibiting ADAR1 reduces liver fibrosis by activating HSC-intrinsic innate immunity, with a 50% decrease in fibrosis observed in treated mice.
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