Momi3 accelerates complex demographic model inference from large allele frequency spectra by up to an unspecified speedup, enabling analysis of multiple populations and samples.
- Open access
- 3 cites
Forensic and Genetic Research
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Advances in sequencing and genome editing have significantly improved detection and understanding of extrachromosomal circular DNA (eccDNA), revealing new insights into genome organization.
High-resolution GWAS of nearly 600,000 East Asians reveals 196 loci for type 2 diabetes, with 3 new loci and 74% shared causal signals across populations.
- Open access
The Soifua Manuia reference panel with 2,570 Samoan haplotypes doubles the number of well-imputed variants compared to TOPMed-R3 and 1KGP in Samoans.
- Open access
Ancient genomes from East Tianshan reveal a unique Bronze Age admixture between Yellow River farmers and Chemurchek steppe pastoralists, with significant regional diversity by the Iron Age.
Ancient inland southwestern Finland shows continuous population genetics over a millennium, while coastal areas experienced significant genetic shifts since the Early Medieval period.
- Open access
SPLENDID improves polygenic risk prediction accuracy across diverse populations by modeling genetic ancestry as a continuum without requiring ancestry labels, outperforming existing methods.
Within-family analysis reveals significant Indigenous American ancestry effects on height and type 2 diabetes in a Mexican population, with effects comparable to population-level estimates.
- Open access
Ancient pathogen genomics in Africa remains underexplored despite its critical role in understanding human disease history, with current research biased toward Eurasia.
- Open access
Genomic analysis of 529 ancient individuals reveals no strong positive selection from Yersinia pestis during the second plague pandemic across northern Europe.
- Open access
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