Parasites and Host Interactions
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Active migration of Plasmodium sporozoites through host cells is essential for achieving sterilizing T cell-mediated immunity after vaccination, regardless of intrahepatic development.
- Open access
- 1 cites
Liver metabolic reprogramming and Th2/1 cell accumulation during H. bakeri infection sustain long-term anti-helminth immunity, with 14-day infection activating immune pathways.
Yersinopine is a primary zinc acquisition system in Yersinia pseudotuberculosis, essential for growth under zinc-limited conditions, unlike in Yersinia pestis where it is inactive.
- Open access
In vitro culture with human serum enables long-term development and clear sexual dimorphism in Schistosoma parasites, unlike traditional FBS-based methods.
- Open access
Multiple local PfDHFR I164L haplotypes have expanded in Uganda, increasing pyrimethamine resistance from 19.4% to 32.4% between 2016 and 2022.
- Open access
The structure of the Plasmodium falciparum moving junction reveals a sailboat-shaped complex that actively remodels host red blood cell membranes during invasion.
A deep learning system accurately grades Schistosoma japonicum-induced liver fibrosis in ultrasound images, with 93.9% of predictions within 0.5 grades of experts.
- Open access
Genetic manipulation of Orientia tsutsugamushi was achieved through transformation and allelic exchange, enabling the development of a foundational genetic toolbox for this pathogen.
- Open access
Proteasomal activity is essential for Leishmania donovani stage differentiation, with proteasome inhibition impairing parasite development and revealing key regulatory mechanisms.
- Open access
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