Liver-Resident Metabolic Reprogramming and Th2/1 Cell Accumulation Drive Anti-Helminth Immunity During H. bakeri InfectionRunning title: Liver metabolic-immune crosstalk in helminth infection

Liver metabolic reprogramming and Th2/1 cell accumulation during H. bakeri infection sustain long-term anti-helminth immunity, with 14-day infection activating immune pathways.

• Why it matters: Understanding how the liver contributes to anti-helminth responses is crucial, as it is an understudied organ in this context and may reveal new therapeutic targets for parasitic infections.
• What they did: The study analyzed liver tissues during infection, showing stage-specific metabolic changes driven by parasite products and immune signals, and identified liver-resident Th2/1 cells maintained throughout infection.
• The result: Findings demonstrate that liver metabolic shifts support T cell effector functions, such as IL-5 production, enabling sustained host defense and suggesting liver pathways as potential targets to improve parasite clearance.