Gp41-directed antibodies neutralize HIV-1 by allosterically stabilizing or opening Env conformations, revealing two distinct modes of neutralization with long-range effects.
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HIV/AIDS drug development and treatment
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Latest in HIV/AIDS drug development and treatment
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Advances in structural biology and imaging have revealed detailed mechanisms of HIV-1 assembly, release, and maturation, enabling targeted antiviral development.
Lenacapavir disrupts HIV-1 capsid maturation by altering interhexamer interactions, preventing functional cone-shaped capsid formation during virion assembly.
- Open access
A novel PCR-based method using a 1D-CNN ensemble achieves 100% accuracy in genotyping UGT1A1 rs3064744 alleles, overcoming platform variability in the Russian population.
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