Research area · week to 3 Oct 2026

Pluripotent Stem Cells Research

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Everyday ethical attentiveness in stem cell-based model research
EMBO Reports · 28 Sept 2026
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https://jclub.com.au/a/10.1038/s44319-026-00945-8
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Latest in Pluripotent Stem Cells Research

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Phenotypes and Cellular Mechanics of Primary Human Aorta- and Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.18.694995
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Proximal tubule-enhanced kidney organoids with S3-like cell enrichment model physiological responses
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.29.702488
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Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkinson's disease.
Cell Stem Cell · 1 Oct 2026 · Journal Article
Genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursors was successfully achieved across multiple donors for Parkinson's disease therapy.
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https://jclub.com.au/a/42753738
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From gatekeepers to regenerators: the plasticity of Paneth cells.
EMBO Journal · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42668274
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Written in development and lost in ageing: the grammar of cellular identity.
Nature · 1 Oct 2026 · Review
Ageing results from the progressive loss of cellular identity constraints, with 90% of age-related DNA methylation changes occurring at PRC2-bound regions in mammals.
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https://jclub.com.au/a/42816559
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Remodeling of a distal IRF4 element spurs human regulatory T cell instability under inflammatory conditions.
Nature Immunology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42786293
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Coordinated tri-inhibition generates human CA1, CA3 and DG neurons and hippocampal astrocytes forming long-lived and electrophysiologically complex cultures
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.21.700748
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Technological prominence alone does not justify leadership in SynCell governance.
Nature Reviews Molecular Cell Biology · 30 Sept 2026 · Letter
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https://jclub.com.au/a/42816599
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Unbiased Long-Read Whole-Genome Sequencing Enables High-Resolution Mapping of Transgene Concatenation and Off-target Genomic Disruption in a Mouse Model
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.15.725597
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Methyl-donor inhibitors relax 3D genome structures to promote totipotent reprogramming.
Cell Reports · 25 Sept 2026 · Journal Article
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https://jclub.com.au/a/42800032
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SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.01.691499
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NANOG is dispensable for hypoblast but essential for embryonic disc development during conceptus elongation in sheep
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754098
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A bicistronic Aldh1a3-P2A-TagBFP knock-in reporter mouse line for studying genitourinary tract development
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.752752
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Embryo editing and embryo selection need joint governance.
Nature Medicine · 23 Sept 2026 · Letter
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https://jclub.com.au/a/42778766
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Emergent 3D genome reorganization and graded gene control from the stepwise assembly of transcriptional condensates.
Cell Reports · 22 Sept 2026 · Journal Article
Stepwise assembly of transcriptional condensates enables graded 3D genome reorganization during yeast heat shock response.
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https://jclub.com.au/a/42632016
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Chromatin architecture dictates epigenetic memory
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.08.717143
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Selective abundance of miR-290-295 in the adult Substantia Nigra dopamine neurons is neuroprotective via preservation of protein synthesis
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.05.668587
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Multi-omics analyses reveal environmentally adaptive cell-state remodeling during human iPSC biomanufacturing
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.26.727850
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Sensory and developmental phenotyping of C. elegans parses autism associated genes into behavioural classifications
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.27.714775
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Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation
bioRxiv · 20 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.13.724824
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Two parallel neural ectoderm progenitors contribute to the developing brain.
Nature Neuroscience · 18 Sept 2026 · Journal Article
Two distinct neural ectoderm progenitors independently generate the forebrain/midbrain and hindbrain regions in mouse and human development.
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https://jclub.com.au/a/42760324
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Gene editing using large insertions.
Nature Biotechnology · 17 Sept 2026 · Interview
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https://jclub.com.au/a/42754737
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Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.721124
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Targeted genomic integration and rearrangement using prime assembly.
Nature · 16 Sept 2026 · Journal Article
Prime assembly achieves targeted integration and large-scale genomic rearrangements in human cells without relying on double-stranded DNA donors or cell cycle cues.
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https://jclub.com.au/a/42749803
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Wt1 splice isoforms bias lineage programmes during formative pluripotency
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.06.713568
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A developmentally regulated long-range enhancer-promoter contact mediates human neural development
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.01.691702
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Nuclear βactin dependent chromatin accessibility governs stem cell pluripotency and extracellular matrix gene programs to maintain cellular biomechanics for cell lineage decisions
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.15.718829
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The metabolic road from α-cells to β-cells.
Nature Chemical Biology · 9 Sept 2026 · Journal Article
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https://jclub.com.au/a/42717053
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Highly efficient base editing at PCSK9 and normal human embryo development.
Nature · 9 Sept 2026 · Journal Article
Base editing at PCSK9 in human embryos achieves high efficiency with normal development, supporting the derivation of homozygous edited stem cell lines.
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https://jclub.com.au/a/42742174
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The mechanistic and evolutionary diversity of programmed DNA elimination.
Nature Reviews Genetics · 8 Sept 2026 · Review
Programmed DNA elimination occurs across diverse eukaryotes with significant mechanistic diversity and evolutionary recurrence, affecting genome integrity and cellular processes.
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https://jclub.com.au/a/42711411
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