Mesenchymal stem cell research

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A continuous single-emulsion microfluidic method forms SCAP spheroids inside ~275 µm alginate microbeads, producing ~80 µm spheroids in ultra-soft ~150 Pa beads that remain retrievable.

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P-selectin–directed nanoparticles (SMNPs) deliver senotherapies to pathogenic P-selectin+ senescent macrophages in fibrotic mouse lung and liver, resolving fibrosis and restoring organ function.

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Pot1a loss in LepR+ mesenchymal stem cells reduces MSC numbers and impairs long-term hematopoietic reconstitution, linked to higher DDR/ROS and less HSC quiescence in knockout mice.

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Exercise-induced exerkine clusterin promotes post–myocardial infarction heart regeneration in adult mice, with cardiac-specific Clu knockout reducing and clusterin overexpression enhancing recovery.

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BCL11A (Bcl11a) overexpression in aged oligodendrocyte progenitor cells significantly enhances oligodendrocyte (OL) differentiation, restoring differentiation capacity impaired by ageing in mice.

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Lockd overexpression in non-regenerative neonatal mouse hearts attenuates isoproterenol-induced pathological hypertrophy and restores cardiomyocyte proliferation via the ENO1/β-catenin/Myc axis.

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Two induced pluripotent stem cell lines were generated from hereditary hemorrhagic telangiectasia donors with heterozygous ACVRL1 mutations, including c.129dup and c.430C > T.

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Postn+ mesenchymal thymic niche cells durably engraft atrophic adult thymus and enhance T cell neogenesis and vaccine responses after adoptive transfer.

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A human induced pluripotent stem cell line, CMCi015-A, was generated from an 18-year-old female with nephronophthisis carrying compound heterozygous loss-of-function variants in NPHP4.

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Two human iPSC lines, CRICKi025-A and CRICKi026-A, were generated from adult bone marrow mesenchymal stromal cells using non-integrating Sendai virus vectors.

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Thirteen human induced pluripotent stem cell clones derived from PBMCs of five healthy donors using non-integrating Sendai virus provide a standardized, deeply characterized reference resource.

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Eleven human iPSC clones generated from fibroblasts of four unrelated healthy donors show genetic stability, strong undifferentiated marker expression, and robust trilineage differentiation.

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Oligodendrocytes actively support CNS function by providing metabolic support for axonal energy demands and enabling adaptive myelination, while becoming dysfunctional in aging and disease.

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Old white adipose tissue (WAT) transplanted into young mice undergoes thermogenic remodeling of mature adipocytes, reversing aged biological age and lipid-droplet structure.