The abstract is read at the publisher; the summary is JClub's.
Four months of 30% caloric restriction in rhesus macaques reprograms metabolism and reduces acute SIV viremia after infection, with effects that wane over time.
- Why it matters: Nutrient metabolism shapes antiviral immunity and chronic inflammation, but it is hard to target therapeutically in lentiviral infection.
- What they did: Rhesus macaques underwent 30% caloric restriction for four months, then were challenged with SIV; researchers compared ad libitum-fed controls using immune phenotyping, interferon signaling, T cell cycling, and metabolic pathway readouts.
- The result: Caloric restriction reduced gut mucosal CCR5+ CD4+ T cell frequencies, dampened type I interferon signaling, and increased CD8+ T cell cycling; after ART it limited gastrointestinal immune activation, improved tricarboxylic acid cycle flux, and lowered plasma sCD14 and TNF-related molecules without changing blood SIV DNA.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.