Fluid-driven robotic micromanipulation for assembloid fabrication.

FDT-VSC enables gentle, programmable assembly of diverse cellular spheroids into structurally defined heterogeneous multicellular tissues, improving consistency for scalable tumor-stroma assembloid fabrication.

• Why it matters: Standardized, reproducible ways to build spatially organized assembloids are lacking, limiting precision and widespread use for modeling complex biological systems and drug screening.
• What they did: The Fluid-Driven Tweezer with Visual Servo Control combines multidimensional visual perception with microfluidic control to orchestrate bottom-up assembly and programmed multilineage tissue construction.
• The result: The platform supports reliable drug screening by improving fabrication consistency in scalable tumor-stroma assembloids, enabling modular tissue engineering, developmental biology, and drug discovery.

AI summary of the abstract · may contain errors · not medical advice · read the paper.