EMBO JJClub
Cis-regulatory co-option of a transposon family reinforces cell identity across the immune system.
EMBO Journal · · Journal Article · Open access
Chobirko, Feschotte + 1 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
ORR1E and ORR1D2 (ODE) TE subfamilies are linked to cell type-specific enhancer activity across the mouse immune system, contacting hundreds of genes.
- Why it matters: It remains unclear how transposable elements gain cis-regulatory roles during immune cell development, despite their widespread genomic presence and regulatory contributions.
- What they did: Using hundreds of mouse and human immune datasets spanning chromatin accessibility, expression, transcription factor occupancy, and DNA-DNA contacts, the study mapped ODE insertion into lineage enhancers and assessed post-insertion motif changes.
- The result: ODE loci show evolutionary sequence constraint and promoter contacts in immune cells, and predicted ODE targets are enriched for cell type-specific functions with increased expression in mouse versus human cell types lacking ODEs.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.
- Open access