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Metabolic sensor Gpr35 links dietary lipids to itch mediating neural circuits.
Communications Biology · · Journal Article · Open access
Wheeler, Lyfenko + more
Abstract ↗AI summary
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EKODE, a dietary linoleic acid derivative, is a potent ligand for Gpr35 and drives chronic itch, inflammation, and heat hypersensitivity in mice.
- Why it matters: The sensors that connect western dietary lipid metabolites to pathological triggers of chronic itch and inflammation are unclear.
- What they did: The study identified Gpr35 as selectively expressed in a sensory neuron subset; sensory-neuron Gpr35 ablation reduced EKODE- and psoriasis-associated itch and inflammation, and pharmacologic Gpr35 inhibition attenuated itch in mouse models of psoriasis and atopic dermatitis.
- The result: Gpr35 signaling engages the itch-specific brain natriuretic peptide, supporting a labeled-line itch pathway distinct from classical nociceptive circuits.
The findingWhy it mattersWhat they didThe result
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