Sustaining microglial reparative function enhances stroke recovery.

Nature · 1 July 2026 · Journal Article · Open access

Tsuyama, Sakai + more

The abstract is read at the publisher; the summary is JClub's.

ZFP384 drives dysfunctional microglia after stroke by diminishing recovery-phase gene expression, and antisense oligonucleotides targeting Zfp384 sustain reparative function to enhance chronic recovery.

Why it matters: Spontaneous functional recovery after brain injury fades within months, and the cellular and molecular mechanisms behind the loss of microglia-driven repair remain unclear.
What they did: Using cellular fate analysis, the study identifies ZFP384 as a transcriptional regulator that reduces YY1-mediated chromatin interactions needed for recovery-phase gene induction in microglia.
The result: Antisense oligonucleotides targeting Zfp384 sustain microglia’s broad neural repair effects and enhance recovery after stroke, including in the chronic phase of ischaemic stroke.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

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Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.
Neuron · 11 Nov 2026 · Journal Article
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KAT7 (HBO1) is elevated in microglia from 5×FAD mice and human AD brains and drives mtDNA-driven innate immune signaling via Cmpk2-dependent mitochondrial activation.
- Open access
- 2 cites
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Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.
Nature Genetics · 1 Sept 2026 · Journal Article
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A disease-associated microglial subtype with elevated GPNMB expression expands with Alzheimer’s disease pathology in human prefrontal cortex, increasing phagocytic activity.
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- 35 cites
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https://jclub.com.au/a/42581323
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Sibling chimerism among microglia in marmosets.
eLife · 14 Aug 2026 · Journal Article
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Sibling-derived chimerism in marmoset brain is found in microglia at 20–52% and macrophages at 18–64%, but not in other resident brain cell types.
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- 9 cites
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Sustaining microglial reparative function enhances stroke recovery.

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Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.

Sibling chimerism among microglia in marmosets.

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