Atherosclerosis and Cardiovascular Diseases

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In adults with atherosclerotic cardiovascular disease, chronic kidney disease, and high-sensitivity CRP ≥2 mg/L, ziltivekimab did not reduce 3-point MACE versus placebo (HR 0.99).

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Pelacarsen (80 mg monthly) did not reduce major adverse cardiovascular events versus placebo in 8322 patients with preexisting cardiovascular disease and lipoprotein(a) ≥70 mg/dL.

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Cholesterol stabilizes the arachidonic acid-binding pocket of THIK-1, and the THIK-1 inhibitor C101248 markedly reduces atherosclerotic plaque in Apoe-deficient mice on a high-cholesterol diet.

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Multiscale modeling shows that endothelial repair under shear stress depends on nonlinear AKT/NO/ROS interactions, with a critical intervention window on Day 1.

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In a multi-ancestry meta-analysis of 378,962 UK Biobank participants, genetic variation in ALOX5 and ALOX5AP is not supported as a driver of ASCVD risk after ancestry is properly accounted for.

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Twelve plasma metabolites are robustly associated with subclinical coronary atherosclerosis in 8,146 SCAPIS participants, including malate and specific sphingomyelins.

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LPL-high endothelial cells in liver metastasis enable intratumoral homing of activated antitumor CD8+ T cells, driving liver metastatic regression.