LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis.

LPL-positive endothelial cells promote T-cell homing and liver metastasis regression by enhancing antigen presentation and immune targeting.

• Why it matters: Understanding how to activate immune responses in cold tumors with low MHC-I expression is critical for improving immunotherapy effectiveness and overcoming resistance.
• What they did: The study traced transcriptional responses of liver metastasis-associated endothelial cells, identifying an LPL-expressing subpopulation that facilitates CD8+ T-cell infiltration through MHC-I-dependent cross-presentation.
• The result: LPL+ TECs enable T-cell homing and tumor regression, suggesting that boosting TEC-mediated antigen presentation could enhance immunotherapy in resistant tumors.