Research area · week to 3 Oct 2026

Advanced Biosensing Techniques and Applications

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pyKinaXe: a fast and robust turnkey kinase activity profiler
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.12.724658
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Proteoform-specific enrichment of phosphopeptide isomers by polymer-based synthetic receptors.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Polymer-based synthetic receptors achieve site-specific enrichment of phosphopeptide isomers, resolving adjacent phosphorylation sites with high precision in complex proteomes.
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https://jclub.com.au/a/42443598
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A dual-photoreactive adapter enables one-step DNA barcoding of antibody panels for multiplexed imaging
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.730979
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ProPER: Ligation-free in situ proximity extension enables multiplexed molecular-state analysis
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.24.718482
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ProteoScopeR: A Shiny Workflow for Method Comparison and Reproducible Quantitative Proteomics Analysis
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752977
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Transparent Weighting of Heterogeneous Evidence for Auditable Candidate Prioritization
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.14.725271
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Unravelling drug resistant proteotypes through phenotype-resolved proteomics of single-cell derived colonies
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.11.681009
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Multiscale Modelling of Multiple Sclerosis Initiation and Progression
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.04.697229
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Designer binding for multiplexed molecular imaging.
Nature Methods · 1 Sept 2026 · Journal Article
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All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT.
Nature Methods · 1 Sept 2026 · Journal Article
REDCAT enables subcellular, multimodal mapping of cell-type-specific metabolism in tissues, revealing distinct metabolic profiles in lymph nodes, lymphoma, and liver.
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https://jclub.com.au/a/42660991
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Capturing protein communication.
Nature Methods · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42697994
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Advancing the applications of liquid biopsies in oncology.
Nature Reviews Genetics · 1 Sept 2026 · Review
Multi-omic approaches and miniaturization are transforming liquid biopsies, enhancing sensitivity and enabling real-time, minimally invasive cancer monitoring.
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A Comprehensive Mathematical Model of Avidity in Cytokine Signaling
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.29.721617
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Combinatorial group testing for efficient scaling across biological applications.
Nature Communications · 25 Aug 2026 · Journal Article
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https://jclub.com.au/a/42660940
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Next-generation multiplexed targeted proteomics quantifies post-translational modifications in disease and compound-protein interactions with high throughput.
Nature Communications · 25 Aug 2026 · Journal Article
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High-Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples.
Cytometry. Part A : the journal of the International Society for Analytical Cytology · 21 Aug 2026 · Journal Article
High-dimensional spectral flow cytometry reliably characterizes immune cells from fixed whole blood, maintaining stability over 2.5 years with 71 markers.
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https://jclub.com.au/a/42630051
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Inadequate antibody validation places substantial numbers of animal and human tissue samples at risk of waste
bioRxiv · 20 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.19.706766
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Cells as Single-Molecule Protein Proximity Networks
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.19.660329
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Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza vaccine development.
Nature Communications · 13 Aug 2026 · Journal Article
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https://jclub.com.au/a/42722670
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Engineered protein circuits for cancer therapy
bioRxiv · 9 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.16.647665
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Optimizing broadly neutralizing antibodies via all-atom interaction modeling and pre-trained language models
bioRxiv · 7 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.20.700456
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The Virtual Tissues foundation model resolves spatial proteomics across scales.
Nature · 5 Aug 2026 · Journal Article
VirTues, a foundation model for spatial proteomics, accurately predicts therapy response and patient outcomes in triple-negative breast cancer with 2–3 times higher accuracy than existing methods.
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