Lung tumors in mice manipulate neurons to induce cachexia, with high-fat diets unexpectedly exacerbating the condition.
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Cancer, Stress, Anesthesia, and Immune Response
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Advances in surgical planning and molecular understanding have expanded the resectability of liver cancers, with a focus on hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
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Replication stress drives tumor evolution and creates therapeutic vulnerabilities, with over 100 clinical trials exploring ATR, CHK1, and WEE1 inhibitors.
Piezo2-expressing neurons and glial cells initiate early macrophage activation, driving inflammation in postoperative ileus in mice.
Adult intracranial arteries supply Ntn4, a neurovascular factor critical for maintaining specific sympathetic neurons, with Ntn4 decline linked to neuronal loss in mice.
- Open access
Intratumoral sotigalimab combined with pembrolizumab induces a 50% objective response rate in metastatic melanoma, activating immune cells in both injected and non-injected tumors.
Chronic stress induces stress-associated macrophages from bone marrow monocytes that promote glioma growth, with C5aR1 signaling playing a key role.
Perioperative tislelizumab plus chemotherapy significantly improves pathological response in tsMHC-II-positive gastric cancer patients, with a 61.8% mPR rate versus 26.5% for chemotherapy alone.
- Open access
GABA signaling is linked to resistance to immune checkpoint inhibitors in TLS-positive tumors, with non-responders showing increased GABA-related activity.
- 3 cites
Perioperative ADT plus apalutamide improves pathological response and metastasis-free survival in high-risk prostate cancer patients undergoing prostatectomy, with 8.9% achieving complete response.
- 26 cites
A biobank of 256 patient-derived tumour organoids reveals diverse gene dependencies across multiple cancer types, advancing precision oncology.
- Open access
- 2 cites
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