The abstract is read at the publisher; the summary is JClub's.
ERAS-based nursing care in 126 muscle-invasive bladder cancer patients undergoing radical cystectomy with Bricker ileal conduit is linked to a smaller postoperative CD8+ T-cell decline (22.8% vs 41.6%, P < 0.001).
- Why it matters: Perioperative immune disruption after surgery is linked to complications, but ERAS immunogenomic correlates in muscle-invasive bladder cancer remain incompletely defined.
- What they did: In a retrospective historical-control cohort (63 ERAS-based, 63 conventional), peripheral immune profiling was measured at T0, T1, and T2, alongside tumor TMB, NanoString immune-gene profiling, and spatial transcriptomics in 24 specimens.
- The result: A four-marker T1 immune index predicted 30-day infectious complications (AUC = 0.84, 95% CI 0.76-0.92), and ERAS showed a higher immune-inflamed TIME phenotype (52.4% vs 28.6%, P = 0.012), with exploratory survival associations requiring validation.
The findingWhy it mattersWhat they didThe result
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