The abstract is read at the publisher; the summary is JClub's.
Early enteral nutrition within 24 h after radical gastrectomy for gastric cancer is linked to a higher POD 7 peripheral CD4+/CD8+ ratio (1.42 vs 1.26; P < 0.001).
- Why it matters: Perioperative immune perturbations after gastrectomy may contribute to heterogeneous outcomes, and a modifiable nutrition timing strategy could help preserve immune phenotypes.
- What they did: In a retrospective cohort of 120 patients (Jan 2022–Dec 2023), EEN (n = 60) was compared with traditional delayed nutrition on POD 3–5 (n = 60), with the primary endpoint the POD 7 CD4+/CD8+ ratio.
- The result: EEN also showed higher POD 7 CD4+ (512 vs 456 cells/μL), CD3+ (1,235 vs 1,086 cells/μL), and NK-cell counts (285 vs 248 cells/μL), fewer 30-day complications (15.0% vs 31.7%), and shorter hospital stay (10.3 vs 13.8 days).
The findingWhy it mattersWhat they didThe result
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