GABA signaling is linked to resistance to immune checkpoint inhibitors in TLS-positive tumors, with non-responders showing increased GABA-related activity.
- 3 cites
Tryptophan and brain disorders
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Disruption of ROS rhythmicity through dual inhibition of IDO1 and AhR extends survival in cancer models, revealing a new therapeutic approach targeting tumor oxidative balance.
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Microbial and metabolic signatures, especially microbial metabolites like p-cresols and indoles, drive CNS autoimmunity severity in a mouse model of MS, with diet-microbiome interactions shaping disease outcomes.
- Open access
Single-cell transcriptomic analysis of 6.3 million nuclei from 1,494 donors reveals shared and distinct molecular signatures across eight brain disorders, including Alzheimer’s disease.
- Open access
- 5 cites
A short-lived anti-PD-L1 antibody was safe and well tolerated in early Alzheimer's disease patients at doses up to 30 mg/kg, supporting further clinical development.
- Open access
RNA sequencing reveals shared immune-inflammatory, synaptic, and mitochondrial dysfunctions across diverse depressive disorders, advancing understanding of their molecular basis.
- Open access
Heterogeneity in protein signalling networks, especially reaction coefficients, drives adaptive resistance to CDK4/6 and oestrogen receptor inhibitors, as shown by MDN modelling.
- Open access
- 1 cites
Adolescent depression is linked to 308 plasma proteins involved in immune, metabolic, and extracellular matrix pathways, revealing shared biological signatures across clinical phenotypes.
- Open access
IL-17A causes premature cortical folding, increased thickness, and accelerated neurogenesis in human fetal brain models, revealing its disruptive role in corticogenesis.
- Open access
GABA signaling is linked to resistance to immune checkpoint inhibitors in TLS-positive tumors, with non-responders showing increased GABA-related activity.
- 3 cites
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