WILDkCAT retrieves extensive enzyme turnover numbers for Escherichia coli and human models, covering a wide range of enzymes under specified conditions.
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Moving in Bioinformatics.
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WILDkCAT retrieves extensive enzyme turnover numbers for Escherichia coli and human models, covering a wide range of enzymes under specified conditions.
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Engineering Corynebacterium glutamicum and Escherichia coli has achieved record L-arginine titers up to 92.5 g/L, advancing microbial production capabilities for industrial use.
Artificial carbohydrate synthesis pathways surpass photosynthesis, potentially revolutionizing sustainable carbon fixation and addressing human demand for efficient, scalable production.
Enzymatic CO2 fixation pathways can be optimized to convert CO2 into valuable products, with potential for scalable, sustainable biocatalytic applications.
Engineered Escherichia coli with an orthogonal energy system enables growth and chemical production from CO₂ and methanol, doubling growth rate and high biomass yield.
OxyR is essential for Zymomonas mobilis to manage oxidative stress during oxic growth and delays ethanol production during anoxic biofuel fermentation, with peroxide identified as a key stressor.
Sodium hydroxide induces 45% higher cell lysis in Bacillus coagulans during fermentation by causing energy deficits under carbon source transition.
A novel Rieske oxygenase system in Pseudomonas putida NCIMB 9866 enables successive oxidation of 2,4-xylenol’s ortho-methyl group into a valuable pharmaceutical precursor.
MetaboCensoR reduces feature redundancy by up to 50% in untargeted LC-MS metabolomics, significantly enhancing data interpretability across diverse biological samples.
Quantitative analysis reveals that Saccharomyces cerevisiae maintains a dynamic amino acid economy with specific public and private goods, guiding synthetic community design.
iModulon framework reveals a conserved "regulatory toolkit" of 13 modules across 53 bacterial species from over 33,000 RNA-seq samples.
PIONEER2 outperforms AlphaFold3 in predicting protein-protein interfaces, especially for uncertain and unstructured complexes, enabling comprehensive human interactome analysis.
Bacterial growth rate varies with environmental and genetic factors, with (p)ppGpp playing a key role in coordinating nutrient signals and growth in Escherichia coli.
MbcS, a refunctionalized acyl-CoA synthetase in Staphylococcus aureus, provides a significant fitness advantage during intra-species competition under nutrient-limited conditions.
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