Research area · week to 3 Oct 2026

Cardiovascular Function and Risk Factors

Moving in JAMA, medRxiv, bioRxiv, Circulation, New England Journal of Medicine, Frontiers in Genetics, The lancet. Gastroenterology & hepatology.

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Latest in Cardiovascular Function and Risk Factors

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Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.06.704519
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Propelling MASLD trials into the era of non-invasive tests.
The lancet. Gastroenterology & hepatology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42285115
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Cardiovascular magnetic resonance reference ranges and centile-based categories for atrial and ventricular cardiac structure and function: 2026 Update from the Healthy Hearts Consortium
medRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.07.25325351
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Left Ventricular Volume and Function Assessment Using a Reduced-Slice Approach in Cardiovascular Magnetic Resonance
medRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.26354413
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New-Onset Heart Failure in Patients with Obesity using Tirzepatide or Semaglutide
medRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.26363546
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Sotatercept Improves Right Heart Mechanics Despite Reduced Myocardial Contractility in Pulmonary Arterial Hypertension: A Prospective Exercise Hemodynamic Study.
Circulation · 22 Sept 2026 · Journal Article
Sotatercept reduces right ventricular contractility by 24 weeks in pulmonary arterial hypertension patients but maintains RV-PA coupling and improves overall right heart mechanics.
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https://jclub.com.au/a/42770225
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Complexity of Diagnosing Volume Overload.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377949
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Complexity of Diagnosing Volume Overload.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377943
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Complexity of Diagnosing Volume Overload.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377968
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Complexity of Diagnosing Volume Overload-Reply.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377972
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Complexity of Diagnosing Volume Overload.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377953
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Complexity of Diagnosing Volume Overload.
JAMA · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42377986
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Tricuspid-Valve Intervention in Heart Failure.
New England Journal of Medicine · 30 Aug 2026 · Journal Article
Transcatheter tricuspid-valve repair significantly reduces death and hospitalization risks in patients with severe tricuspid regurgitation, with a win ratio of 2.42 at 1 year.
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https://jclub.com.au/a/42670975
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Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation.
New England Journal of Medicine · 30 Aug 2026 · Journal Article
Performing TAVI before PCI is noninferior to PCI before TAVI regarding 1-year outcomes in patients with severe aortic stenosis and coronary artery disease, with a 22.2% versus 24.2% event rate.
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https://jclub.com.au/a/42670987
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Heterogeneous Treatment Effects in HFpEF: Distinguishing Drug-Specific Response from Prognostic Phenotypes Across Randomized Trials
medRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.06.26357251
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Association between sarcopenia and the risk of diabetic cardiomyopathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study.
Frontiers in Genetics · 25 Aug 2026 · Journal Article
Sarcopenia independently increases the risk of diabetic cardiomyopathy by 2.25 times in patients with type 2 diabetes mellitus.
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https://jclub.com.au/a/42708081
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Deep Learning-Based Single-View Echocardiographic Analysis for Prediction of Left Ventricular Outflow Tract Gradient Elevation After Transcatheter Aortic Valve Replacement
medRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.27.26349567
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A Theoretical Framework for the Hemodynamic Role of Sarcomere Length Dynamics During the Isovolumic Phases of the Left Ventricle
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.16.712012
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Analytical resolution governs cross-laboratory and cross-species concordance in murine cardiometabolic HFpEF transcriptomics
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721824
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AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026).
Circulation · 18 Aug 2026 · Consensus Statement
The Second Universal Definition of Heart Failure (2026) standardizes classification into reduced, preserved, and improved ejection fraction categories, moving beyond rigid cutoffs.
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https://jclub.com.au/a/42366997
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Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association.
Circulation · 11 Aug 2026 · Consensus Statement
Perinatal heart failure affects up to 2% of women, yet its definition, diagnosis, and management remain unclear, risking adverse maternal outcomes.
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