The abstract is read at the publisher; the summary is JClub's.
In pulmonary artery banded pigs, worsening right ventricular dysfunction from RV ejection fraction 38±4% to 20±8% is linked to distinct cellular programs and targetable stress pathways.
- Why it matters: It is unclear whether RVD severity reflects different cellular and molecular alterations, limiting selection of optimal therapeutic targets.
- What they did: Using single-nucleus RNA sequencing plus mitochondrial/cytoplasmic proteomics and phosphoproteomics on control, mild, and severe RVD pig RV tissue, with histology validation, the study integrated transcriptomic and proteomic signals.
- The result: Severe RVD shows impaired mitochondrial proteostasis, increased cardiomyocyte HIF1A transcript expression, and activation of ribotoxic stress response with impaired macrophage efferocytosis and insufficient mitochondrial unfolded protein response, suggesting conserved mechanisms.
The findingWhy it mattersWhat they didThe result
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