Exercise trains the liver to save the heart.

Exercise induces the liver to release clusterin into the bloodstream, and this is linked to improved cardiac remodeling and myocyte proliferation after myocardial infarction.

• Why it matters: The work addresses how exercise benefits the heart and clarifies a mechanistic link for clusterin’s controversial role in cardiac injury.
• What they did: Wang and colleagues show that exercise prompts hepatic clusterin release into blood, then assess cardiac remodeling and myocyte proliferation following myocardial infarction.
• The result: The results suggest a liver-to-blood-to-heart pathway for exercise effects, supporting clusterin as a mediator of post-infarction recovery.

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