The abstract is read at the publisher; the summary is JClub's.
In adults with congenitally corrected transposition of the great arteries and systemic right ventricular systolic dysfunction, higher baseline and uptitrated GDMT scores are linked to improved RV free wall strain and lower mortality.
- Why it matters: Systemic right ventricular failure in cc-TGA remains a major driver of adverse outcomes, but the extent to which guideline-directed medical therapy improves function and survival is unclear.
- What they did: Adults with cc-TGA had GDMT score, RV free wall strain (RVFWS), and NT-proBNP measured at baseline and 1-year; improvement was defined as >20% relative RVFWS increase and >20% relative NT-proBNP decrease.
- The result: Among 213 patients, 34 (16%) died; higher baseline GDMT score and ΔGDMT score were associated with lower mortality and a composite adverse endpoint, with benefits limited to moderate/severe RV systolic dysfunction.
The findingWhy it mattersWhat they didThe result
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