Mapping contrast sensitivity across the entire visual field with fMRI reveals reliable patterns even with fixation variability in seven participants.
- Open access
Retinal Development and Disorders
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Latest in Retinal Development and Disorders
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Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
- Open access
Retinal waves, apoptosis, and angiogenesis are tightly synchronized during postnatal mouse retinal development, with apoptotic cells triggering neural activity and vascular growth.
- Open access
The pulvinar primarily relays signals from V1 to V2 in macaques, with V1 activity leading pulvinar and pulvinar leading V2, supporting a feedforward communication role.
- Open access
Synergistic inhibition of Notch signaling and forced cell cycle re-entry induces significant Müller glia reprogramming, generating diverse retinal neuron-like cells in uninjured mouse retina.
- Open access
Bhlhe22 and Kappa Opioid Receptor-expressing wide-field amacrine cells in mouse retina encode stimulus orientation with Ca2+ signals aligned to dendritic structure.
- Open access
- 6 cites
Humans and models match in discriminating visual features with pooling windows scaled to about one-fourth in luminance compared to spectral energy across large stimuli.
- Open access
Calcium inhibits viral channelrhodopsins by binding near the retinal cofactor, blocking essential conformational changes and preventing ion translocation.
- Open access
Hedgehog signaling drives exponential growth and neuronal production in the developing vertebrate retina by regulating neural progenitor cell cycles.
- Open access
- 1 cites
Genomic advances have identified causal genes and variants, paving the way for targeted therapies for retinal and macular degeneration affecting millions globally.
- Open access
Suprachoroidal delivery of AL-001 achieves sustained aflibercept expression and superior efficacy with minimal inflammation in a nonhuman primate model of wet age-related macular degeneration.
- 1 opens in JClub
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Hbs1-Pelo complex regulates ATF4 translation, and its disruption causes phototransduction defects leading to vision loss in Drosophila and humans.
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