Persistent expansion of alloreactive T cell clones and phenotypic plasticity drive severe graft-versus-host disease in human transplant recipients.
Hematopoietic Stem Cell Transplantation
Moving in Blood, Nature Immunology, bioRxiv, Cancer Research, Cytometry. Part A : the journal of the International Society for Analytical Cytology, EMBO Journal, medRxiv, Nature.
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Latest in Hematopoietic Stem Cell Transplantation
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FGF18 from stromal fibroblasts promotes AML progression by activating FGFR3 signaling and suppressing immune responses, with elevated levels linked to poor prognosis.
- Open access
Fibro-inflammatory remodeling in bone marrow is a defining feature of clonal hematopoiesis of indeterminate potential, with a significant expansion of fibroblasts and extracellular matrix changes.
- Open access
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IDH3A-driven citrate accumulation controls metabolic fitness and venetoclax resistance in AML stem cells, with knockdown impairing leukemia maintenance.
CD4+CD25+FOXP3+ regulatory T cells significantly reduce graft-versus-host disease risk in allogeneic hematopoietic cell transplantation.
Translational regulation of Sf1 via a conserved 5' UTR modulates hematopoietic stem cell fate by controlling spliceosome activity and gene splicing.
- Open access
IFN-γ-driven inflammation causes long-term bone marrow niche dysfunction after doxorubicin chemotherapy, impairing hematopoietic and skeletal health.
- Open access
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P-selectin marks early functional heterogeneity in aging hematopoietic stem cells, with high expression linked to increased DNA damage and myeloid bias in humans and mice.
- Open access
Epitope editing of KIT combined with BCL11A disruption enables non-genotoxic, in vivo selection of gene-edited HSPCs, enhancing therapeutic potential for blood disorders.
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GLS and GEE-GLM modeling approaches reveal significant differences in hematopoietic maturation profiles across disease states, with GEE-GLM highlighting early-stage variations.
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Stage-specific degradation of cyclin D3 prevents myeloproliferative neoplasms by regulating myelopoiesis, with sustained levels causing MPN development in mice.
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l-Carnitine enhances human hematopoietic stem cell regeneration by activating fatty acid oxidation and mitochondrial metabolism, as shown in primary cell assays.
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