Nature Immunology · 30 Sept 2026 · Journal Article

Clonal blood reshapes its home.

Zhang, Kain + 1 more

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Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease.
Nature Immunology · 1 Oct 2026 · Journal Article
Persistent expansion of alloreactive T cell clones and phenotypic plasticity drive severe graft-versus-host disease in human transplant recipients.
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FGF18 mediates fibroblast-leukemia cross talk to promote acute myeloid leukemia progression.
Blood · 1 Oct 2026 · Journal Article
FGF18 from stromal fibroblasts promotes AML progression by activating FGFR3 signaling and suppressing immune responses, with elevated levels linked to poor prognosis.
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Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.
Nature Immunology · 30 Sept 2026 · Journal Article
Fibro-inflammatory remodeling in bone marrow is a defining feature of clonal hematopoiesis of indeterminate potential, with a significant expansion of fibroblasts and extracellular matrix changes.
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- 1 cites
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https://jclub.com.au/a/42816584
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