eLifeJClub
SVEP1 enables efficient binding of angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling.
eLife · · Journal Article · Open access
Uphoff, Hußmann + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
SVEP1 enables efficient binding of ANG2 to the TIE1 receptor, and combined SVEP1+ANG2 stimulation in hdLECs drives TIE1 phosphorylation.
- Why it matters: Understanding how SVEP1 and TIE1 coordinate (lymph-)angiogenesis is important for diseases like lymphedema linked to lymphatic vascular malformations.
- What they did: Using AlphaFold-multimer predictions plus protein binding studies, the human CCP20 domain is identified as the primary TIE1 binding site, and SVEP1-mediated ANG2–TIE1 binding is tested in hdLECs.
- The result: TIE1 activation by SVEP1 and ANG2 triggers downstream signaling, potentiating nuclear exclusion of FOXO1 and phosphorylation of AKT compared with SVEP1 or ANG2 alone.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.
- Open access
- 2 cites