bioRxivJClub
Determining Reliable Neural Targets for enhancing Motor Sequence Learning: A preparatory study for focal tDCS
bioRxiv · · Preprint · Open access
Khan, Burke + 4 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In a 3T fMRI Serial Reaction Time Task in 20 healthy adults, implicit sequence learning was robust across sessions, with random-block reaction time showing excellent test–retest reliability (ICC = 80 to .85).
- Why it matters: tDCS effects on motor sequence learning vary, so reliable behavioural and neural signatures are needed to define dependable stimulation targets and interpret outcomes consistently.
- What they did: Participants completed two matched, counterbalanced SRTT versions in two sessions about one week apart; the study assessed block-wise reaction time, task activation, SEQ > RND contrasts, and seed-based connectivity plus whole-brain gPPI.
- The result: Sequence-specific activation (SEQ > RND) produced stable sensorimotor and cerebellar clusters, while gPPI found four sequence-specific connectivity clusters, supporting a two-component left cortico-striato-cerebellar and right visuomotor/monitoring architecture.
The findingWhy it mattersWhat they didThe result
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