The abstract is read at the publisher; the summary is JClub's.
Integrated transcriptomic and proteomic analyses identify CTHRC1, ACTA1, and MSN as tissue and urine biomarkers linked to bladder outlet obstruction, with modest statistically significant concordance.
- Why it matters: Obstruction remodeling and lower urinary tract symptoms can persist even after relief, and reliable surrogate biomarkers—especially early—are lacking.
- What they did: Re-analyzed public rodent transcriptomic datasets to find injury-induced transcripts, then experimentally validated time-dependent changes in an independent neurogenic obstruction model and tested candidates in pediatric neurogenic bladder tissue and rat proteomic datasets.
- The result: Several candidates were increased in pediatric neurogenic bladder and differentially abundant in rat partial obstruction proteomics, were attenuated after obstruction removal or anticholinergic/inosine treatment, and showed modest but statistically significant tissue–urine concordance.
The findingWhy it mattersWhat they didThe result
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