Randomized Sham-Controlled Trial of Translumbosacral Neuromodulation Therapy for Fecal Incontinence.

Translumbosacral neuromodulation therapy with 2400 and 3600 magnetic pulses significantly reduces fecal incontinence episodes compared to sham, with responder rates up to 81.1%.

• Why it matters: Fecal incontinence is a complex condition lacking effective, disease-modifying treatments, creating a need for safe, noninvasive options to improve patient outcomes and quality of life.
• What they did: A multicenter, double-blind, randomized sham-controlled trial involving 109 patients tested TNT at two stimulation levels over six weeks, assessing changes in FI episodes, severity, and neurophysiology.
• The result: TNT significantly decreased FI episodes and severity, improved nerve conduction and anal pressures, and was well tolerated, demonstrating its potential as an effective therapy for FI management.