Noncanonical cytochrome P450 enzymes lacking the conserved cysteine are widespread, with 20 distinct families identified in diverse microbial genomes.
Neurological diseases and metabolism
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Coenzyme A activates TLR4 and boosts IL-4-driven macrophage activation via MyD88, revealing a new metabolic pathway influencing immune responses.
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Gut-derived pantothenic acid from Bacteroides fragilis improves metabolic syndrome by restoring gut barrier function and reducing inflammation.
Growth-coupled biosynthesis in Pseudomonas putida achieves gram-scale xanthommatin production by linking pigment synthesis to C1 metabolism, reaching significant bioproduction levels.
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