Research area · week to 3 Oct 2026

Renal and related cancers

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Latest in Renal and related cancers

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Proximal tubule-enhanced kidney organoids with S3-like cell enrichment model physiological responses
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.29.702488
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[18F]RCCB6 PET/CT in Diagnosing Clear-Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.
Cancer Discovery · 1 Oct 2026 · Comparative Study
[18F]RCCB6 PET/CT detects ccRCC metastases with 94.2% sensitivity, outperforming [18F]FDG PET/CT and conventional imaging in accuracy and specificity.
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https://jclub.com.au/a/42112793
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Robustness measures for cell type classification in single-cell RNA-seq datasets of kidney organoids
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752971
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A bicistronic Aldh1a3-P2A-TagBFP knock-in reporter mouse line for studying genitourinary tract development
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.752752
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mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis.
Nature · 23 Sept 2026 · Journal Article
Loss of TSC2 in neural progenitors causes cell-autonomous formation of reactive astrocytes with neurodegenerative features in tuberous sclerosis.
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https://jclub.com.au/a/42778607
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Wt1 splice isoforms bias lineage programmes during formative pluripotency
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.06.713568
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CD239 deficiency in distal tubules impairs cell polarity and increases susceptibility to renal injury
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.31.728029
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The insulin/IGF axis is critically important for controlling gene transcription in the podocyte.
eLife · 4 Sept 2026 · Journal Article
Dual-receptor knockdown of insulin and IGF1 receptors in podocytes causes severe kidney disease and cell loss, highlighting their critical role in renal health.
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https://jclub.com.au/a/42695984
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CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.23.727418
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Long-term imaging of cell divisions in human preimplantation embryos.
Nature Biotechnology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41131149
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Direct identification of de novo mobile element insertions from single molecule sequencing of human sperm
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.25.684559
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Whole-genome sequencing characterizes monogenic and polygenic contributions to structural kidney and urinary tract malformations
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.10.24315242
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Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk.
Genome Medicine · 19 Aug 2026 · Journal Article
Human kidney organoids subjected to hypoxia replicate key features of ischemic AKI, including segment-specific injury responses and persistent inflammation, with 48 hours of hypoxia inducing notable injury markers.
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https://jclub.com.au/a/42613631
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Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids
bioRxiv · 19 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.09.658557
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Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.
Molecular therapy. Nucleic acids · 19 Aug 2026 · Journal Article
Liver-targeted AGT siRNA increases CoRL-derived podocytes by 85% in kidney disease, promoting regeneration without immediate functional improvements.
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https://jclub.com.au/a/42724523
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SALLB not targeted by IMiDs is important for maintenance of liver cancer cells
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.07.07.548071
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Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer.
Frontiers in Genetics · 17 Aug 2026 · Journal Article
Conserved ferroptosis and immune modules are linked to developmental dysregulation in Wilms tumor, with partial conservation across oral cancer, highlighting potential therapeutic targets.
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https://jclub.com.au/a/42670482
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