Research area · week to 3 Oct 2026

PARP inhibition in cancer therapy

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Latest in PARP inhibition in cancer therapy

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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
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https://jclub.com.au/a/42467549
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Mechanisms and disease relevance of DNA break repair pathway choice.
Nature Reviews Molecular Cell Biology · 18 Sept 2026 · Review
DNA double-strand break repair pathway choice is governed by complex mechanisms involving chromatin modifications and key repair factors, with BRCA1-BARD1 and 53BP1 playing antagonistic roles.
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https://jclub.com.au/a/42760358
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Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation.
Molecular Cell · 17 Sept 2026 · Journal Article
Yeast Rad55-Rad57-SHU complex enhances Rad51 filament formation through dynamic structural and nucleotide-regulated mechanisms.
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https://jclub.com.au/a/42480524
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PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
Cancer Research · 15 Sept 2026 · Journal Article
PARG stabilizes RAD51AP1 through a PARylation-ubiquitination switch, promoting homologous recombination repair and contributing to chemoresistance in gastric cancer.
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https://jclub.com.au/a/42314057
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HDAC2 inhibition restores H4K16ac and delays senescence in HGPS VSMCs
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.07.687234
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DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study.
Frontiers in Genetics · 1 Sept 2026 · Journal Article
Combined DDR gene mutation profiling with TMB and PD-L1 predicts immunotherapy response in 152 metastatic castration-resistant prostate cancer patients, with an AUC of 0.83.
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https://jclub.com.au/a/42741774
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Next-generation cancer therapeutics.
Nature Cancer · 1 Sept 2026 · Editorial
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https://jclub.com.au/a/42778786
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DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1.
EMBO Reports · 27 Aug 2026 · Journal Article
BRCA1 exon 11 interacts with TOPBP1 to specifically promote DNA end-resection during homologous recombination, crucial for tumor suppression.
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https://jclub.com.au/a/42661062
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Timing the onset of homologous recombination deficiency before breast cancer diagnosis
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.17.683157
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PARP14-dependent ADP-ribosylation of cytoplasmic SQSTM1/p62 foci supports innate immune signaling
bioRxiv · 19 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.29.601315
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Comprehensive Analysis Reveals Adaptive DNA Repair and Replication Stress Networks in Genomically Unstable Breast Cancer
bioRxiv · 10 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.13.724208
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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity.
Molecular Cell · 6 Aug 2026 · Journal Article
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https://jclub.com.au/a/42302790
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3-aminobenzimide attenuates behavioral, cardiovascular, and neuroinflammatory effects of chronic stress
bioRxiv · 6 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.28.721400
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Exploring Potential Minocycline-ARH3 Interactions in ADPRHL2-Associated CONDSIAS: A Translational Clinical and Computational Study
medRxiv · 6 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.09.26357651
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