Research area · week to 3 Oct 2026

Congenital heart defects research

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Latest in Congenital heart defects research

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ID2 orchestrates the final 'E-scape' from the -165-kb Zeb2 enhancer for cDC1 specification.
Nature Immunology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42711530
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Propelling MASLD trials into the era of non-invasive tests.
The lancet. Gastroenterology & hepatology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42285115
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From gatekeepers to regenerators: the plasticity of Paneth cells.
EMBO Journal · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42668274
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Cellular-Resolution Spatial Transcriptomics Reveals Laminar VSMC Phenotypic Remodeling and a Hypoxic Medial Core in Human Thoracic Aortic Dissection
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.13.738344
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Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753362
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Machine Learning identification in patients with aortic valve stenosis of a myocardial miRNA signature predictive of reverse cardiac remodelling after valve replacement
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363736
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Exploring the functions of JAKMIP1 in neuronal IL-6/STAT3 signaling and its relevance to chromosome 15q-duplication syndrome
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.21.683757
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Neural plate morphogenesis and pre-patterning enable specification of intermediate progenitors in the spinal cord
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.01.09.632276
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YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.
Communications Biology · 17 Sept 2026 · Journal Article
YAP1 induces hepatocellular carcinoma through DNA demethylation, not canonical driver gene mutations, with widespread demethylation activating oncogenes in mouse models.
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Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target.
Neuron · 16 Sept 2026 · Journal Article
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https://jclub.com.au/a/42155452
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Three-dimensional Virtual Adult Cardiomyocyte Transcriptomics
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.14.718375
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A single-nucleus transcriptomic atlas of human inner ear development.
Nature Neuroscience · 9 Sept 2026 · Journal Article
Single-nucleus transcriptomic atlas reveals key cell types and developmental mechanisms in human inner ear, highlighting vulnerabilities linked to disease genes.
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https://jclub.com.au/a/42717251
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Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration.
eLife · 8 Sept 2026 · Journal Article
Primordial cardiomyocytes are essential for heart development but not necessary for regeneration in zebrafish, with only 15% capable of regeneration after injury.
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Single-Nuclear RNA Sequencing Reveals Regional Specialization and Cellular Interactions in Epicardial and Perivascular Adipose Tissue
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.744748
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Metabolomic analysis of children with congenital heart disease complicated by neurological developmental abnormalities and CHD7 mutations.
Frontiers in Genetics · 28 Aug 2026 · Journal Article
Children with CHD7-mutant congenital heart disease and neurodevelopmental abnormalities exhibit distinct serum metabolomic profiles, especially in steroid hormone and amino acid metabolism, with 11-deoxycortisol and 2-hydroxyestrone as potential markers.
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https://jclub.com.au/a/42725350
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Sulf1 regulates inflammation via modulation of TGF-β dependent epicardial activation.
EMBO Reports · 27 Aug 2026 · Journal Article
Sulf1 modulates TGF-β signaling to regulate epicardial activation and inflammation, affecting heart regeneration in zebrafish.
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https://jclub.com.au/a/42661063
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Collective fate decisions and cell rearrangements underlie gastruloid symmetry breaking
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.16.628776
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Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.04.641443
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Cell-type-dependent bioelectric regulation of fin size and fin-ray segment length in zebrafish
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.27.587111
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Analytical resolution governs cross-laboratory and cross-species concordance in murine cardiometabolic HFpEF transcriptomics
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721824
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Emergence of Functional Heart-Brain Circuits in a Vertebrate
bioRxiv · 23 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.22.677693
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Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type.
Nature Communications · 20 Aug 2026 · Journal Article
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https://jclub.com.au/a/42754619
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Aberrant Phase Separation of Endothelial MAML1 Causes Congenital Heart Disease by Suppressing Notch Activity.
Circulation · 18 Aug 2026 · Journal Article
Aberrant phase separation of MAML1 impairs Notch signaling, causing congenital heart defects in mice and humans, with 3 key variants disrupting MAML1 condensates.
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https://jclub.com.au/a/42246060
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Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathy
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.07.743611
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Integrated computational and in vivo evidence prioritizes MYH6 as a candidate node in PFOS-associated HCM-like cardiac remodeling.
Environmental pollution · 14 Aug 2026 · Journal Article
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https://jclub.com.au/a/42600829
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Tissue spreading reorganises the extracellular matrix to establish the pre-gastrulation avian blastoderm architecture
bioRxiv · 13 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.06.647388
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Alternative Splicing of TPM1 Mediated by SRPK3 Drives Cardiac Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.
Circulation · 11 Aug 2026 · Journal Article
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https://jclub.com.au/a/42261667
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Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics.
Circulation · 11 Aug 2026 · Journal Article
Intersectional genetics enabled precise targeting of arterial and nonvascular smooth muscle cell subtypes, revealing organ-specific gene signatures and disease responses.
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https://jclub.com.au/a/41969103
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Transient disruption of progenitor states and layer 2/3 projection neuron generation in frontal association cortex due to 22q11.2 gene deletion
bioRxiv · 10 Aug 2026 · Preprint
Transient disruption of progenitor states in the fetal frontal cortex due to 22q11.2 gene deletion reduces Layer 2/3 projection neuron generation by 22-50%, impacting cortical connectivity.
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https://jclub.com.au/a/10.1101/2025.05.12.653556
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Higher frequency of homologous chromosome pairing in adult endothelial cells as compared to neonatal endothelial cells
bioRxiv · 7 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.15.643486
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