ABTB1 functions as an E3 ubiquitin ligase that suppresses Th17 cell differentiation by promoting STAT3 degradation, reducing autoimmune inflammation.
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Caspase-3 cleaves CYLD at a novel site to limit interferon signaling during mitochondrial apoptosis, reducing inflammation and promoting immune silence.
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Inhibiting TAK1 in pancreatic ductal adenocarcinoma enhances immune infiltration and activates DNA damage pathways, with significant effects observed in mouse models.
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Whole-exome sequencing of 20 Korean Behçet's disease patients identified six genes with significant variants linked to disease susceptibility.
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Overlapping Xq13.3 duplications increase TAB3 dosage, causing X-linked hypotrichosis simplex with a 3.4 Mb critical region.
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